Preventive effect of agnucastoside c against isoproterenolinduced. On auto oxidation, iso generates highly cytotoxic free radicals known to stimulate peroxidation of membrane phospholipids and cause severe damage to the myocardial membrane. The effect of astragaloside iv on isoproterenolinduced myocardial infarction in rats article pdf available in pharmaceutical sciences 252. However, the rationale of the combined use remains unclear. Aim of the present study, an attempt has been made in acute and chronic periods after isoproterenol isoinduced myocardial infarction mi in male wistar rats. Isoprenaline isoproterenol is a synthetic catecholamine and. These results clearly show the action of no in isoproterenolinduced myocardial infarction and suggest the importance to assess the role of no in pre infarction and early post infarction stages in patients. Edaravone, a potent free radical scavenger and a calcium. The acute phase of myocardial necrosis induced by isoproterenol mimics changes in blood pressure, heart rate, electrocardiogram ecg, and left ventricular dysfunction similar to that occurring in patients with myocardial infarction. Effect of theobroma cacao polyphenol on isoproterenol. Isoproterenolinduced myocardial infarction in rats.
Cardioprotective effect of ritonavir, an antiviral drug. Exploration of pharmacological interventions to prevent. The present study evaluated cardioprotective effect of lyophilized hydroalcoholic extract of moringa oleifera in the isoproterenol ispinduced model of myocardial infarction. It is also known to generate free radicals and to stimulate lipid peroxidation, which may. Curcumin has antiinflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Effect of cardamom treatment on the activities of sod, cat and gshpx enzymes. Isoproterenol, is a adrenergic agonist and has been reported to increase lipid peroxidation through enhanced free radical formation4 isoproterenol.
The rats were randomly divided into four groups of 6 rats each. Diabetes and isoproterenolinduced myocardial infarction was evident as a. Antioxidants, fenugreek, isoproterenol, myocardial infarction. In the present study, we investigated whether combination therapy of lowdose benidipine with the potent free radical scavenger edaravone has a cardioprotective effect against isoproterenol isoinduced myocardial infarction mi in wistar rats. Protective effects of cardamom in isoproterenolinduced myocardial. Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1. Role of nitric oxide in isoproterenolinduced myocardial.
Exploration of pharmacological interventions to prevent isoproterenolinduced myocardial infarction in experimental models show all authors. Evaluation of cardioprotective effect of tinospora. The present study is designed to evaluate the effect of nigella sativa seeds called black cumin on isoproterenol induced myocardial infarction in experimental rats. Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1, 23 h corticosterone 3 h corticosterone. Amelioration of isoproterenolinduced oxidative damage in. Pdf the present study was designed to investigate the cardioprotective effects of sundarban.
Protective effect of taurine on myocardial antioxidant. Molecules free fulltext cardioprotective effects of. The rats were randomly divided into 4 groups, each group consisting of 8 rats. High incidences of myocardial infarction associated with. Myocardial infarction, antioxidants, isoproterenol, natural. Although exercise derived activation of nrf2 signaling augments myocardial antioxidant signaling, the molecular mechanisms underlying the benefits of moderate exercise training met in the heart remain elusive. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles ccnp compared to conventional curcumin cc on isoproterenol. In the present study, we evaluated the role of ritonavir in isoproterenolinduced. Cardioprotective effects of puerarinv on isoproterenol. Ischemic tissues generate oxygen derived free radicals which have been implicated in cardiac diseases and metabolic disorder prabhu 2006.
Pdf the effect of astragaloside iv on isoproterenol. Inadequate blood supply to the heart leads to infarction followed by irreversible necrosis of myocardial tissue. Free radicals generated by iso initiate lipid peroxidation of the membrane bound polyunsaturated fatty acids, leading to impairment of the. Original article baicalin ameliorates isoproterenolinduced acute myocardial infarction through inos, inflammation, oxidative stress and p38mapk pathway in rat shenjie sun, xiaopeng wu, hengliang song, guiqi li department of cardiology, the second hospital affiliated to zhengzhou university, zhengzhou 450014, henan, china. Research article sundarban honey confers protection against isoproterenolinduced myocardial infarction in wistar rats rizwanaafroz, 1,2 e. In this research, we aim to evaluate the cardioprotective effects of puerarinv on the isoproterenol isoinduced mi mice and elucidate the underlying mechanisms. Effect of an ethanol extract of embelia ribes fruits on. Two hundred mgkg iso dose was selected for the present study as this dose. Isoproterenol iso, a synthetic catecholamine and adrenergic agonist, has been documented to produce myocardial infarction in large doses rona g. Isoproterenolinduced myocardial infarction in rabbits.
Original article baicalin ameliorates isoproterenol. A tool for inducing myocardial infarction in experimental animals, authormohd aftab siddiqui and usama sharif ahmad and ahmed abdullah khan and mohammad ayaz ahmad and badruddeen and mohammad khalid and juber akhtar, year2016. We investigated the protective role of withania somnifera leaf extract wslet on isoproterenol iso induced myocardial infarction mi in rats. Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenolinduced myocardial infarction in wistar rats. Wistar albino male rats were divided into three groups and orally fed saline once daily alone sham or with isp isp control or isp with m. Pdf isoproterenolinduced myocardial infarction in wistar rats.
Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1, 23h corticosterone 3h corticosterone. Protective effects of cardamom in isoproterenolinduced. Keshtkar s, komeili g, keshavarzi f, jahantigh m 2017 cardio protective effects of hydroalcholic citrus aurantium extract on myocardial infarction induced by isoproterenol in male rats. Protective effect of sesamol against myocardial infarction. Abstractthis study was designed to investigate the cardioprotective effect of sesamol on isoproterenol isoinduced myocardial infarction in adult male. Experimental model of myocardial infarction induced by.
Research article sundarban honey confers protection. Myocardial infarction was induced by subcutaneous iso administration at a dose of 85 mgkg 1 day 1 with a drug free interval of 24 h on. Luteolin supplimentated by intragastric intubation at a daily dose of 0. Cardioprotective activity of nelumbo nucifera rhizomes in. Protective role of black cumin nigella sativa on isoproterenol induced myocardial infarction in rats abstract international journal of pharmacology and clinical sciences, 2012, 1, 2, 4553. Effects of histidine and vitamin c on isoproterenol. All national and international guidelines for the care and use of animals were closely followed. In this research, a comparative study was conducted to investigate the possible difference of pharmacokinetic process in normal and isoproterenolinduced myocardial infarcted rats after oral administration of ga monohydrate. However, the cardioprotective effects of puerarinv on myocardial infarction mi heart failure are still unclear. Luteolin a dietary flavonoid attenuates isoproterenol.
Sabir hossain, 1 nadia alam, 4 siew hua gan, 4 and md. A model of myocardial fibrosis and heart failure was established by oncedaily subcutaneous injection of isoproterenol 5 mgkgday to rats for 7 days. Acute treatment with metformin improves cardiac function. Here we hypothesized that exercise training stabilizes nrf2dependent antioxidant signaling, which then protects the myocardium from isoproterenolinduced damage. Juan carlos torres and gabriela velascoloyden march 28th. However, the effect of ritonavir on cardiac glut4 inhibition during myocardial necrosis is not investigated. Vasodilators may play positive role in myocardial infarction mi. Abstract mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenousl3hy wit corticosteronh 1.
The isoproterenolinduced myocardial infarction in rodents offers a relevant model to study the effect of natural products. Thirty young, male, wistar rats 145 to 230 g were randomly allocated in two groups. For this,tamoxifen was administered to spraguedawley rats for 114 days, and isoproterenol iso 100 mgkg body mass. Subcutaneous injection of iso 85 mgkg body weight b. Pdf effect of curcuma longa turmeric on serum creatine. Cardioprotective activity of nelumbo nucifera rhizomes in isoproterenol induced myocardial necrosis in male wistar rats shivendra pratap singh, navneet kumar verma, praveen kumar rai, abhay pratap.
Effects of curcumin nanoparticles in isoproterenolinduced. Isoproterenol iso administration induced the myocardial injury as evidenced by. Myocardial infarction is the acute condition of necrosis of the myocardium that occurs as a result of imbalance between coronary blood supply and myocardial demand boudina et al. We here describe the shortterm effects in rabbit of isoproterenol on the parameters associated with myocardial necrosis histology, ecg, plasma cardiac necrosis markers, or involved in peroxidation vitamin e or coagulation phenomena ptt, in the absence or presence of propranolol or labetalol. Role of nitric oxide in isoproterenolinduced myocardial infarction. Based on the results presented, we conclude that the model of myocardial infarction induced by isoproterenol in rats was adequately reproduced and validated in our laboratory and caused increased mortality and myocardial injury markers ast and troponin i, reduction of catalase activity and levels of glutathione and histopathological changes. In isoproterenolinduced myocardial damage, the levels of lipid peroxides were increased and gsh, sod and cat.
Effect of cardamom on glutathione and lipid peroxidation in the isoproterenolinduced myocardial infarction in rats. Protective effects of cardamom in isoproterenolinduced myocardial infarction in rats sameer n. We aimed to investigate the protective effect of ginsenoside re on isoproterenolinduced myocardial fibrosis and heart failure in rats. Vitamin a is beneficial in counteracting free radical damage, therefore the present study is designed to investigate the effect of vitamin a against isoproterenolinduced myocardial infarction in rats.
Cardioprotective effect of fenugreek on isoproterenolinduced. Isoproterenolinduced myocardial infarction in albino rats m. Myocardial infarction is usually induced in small animals by means of invasive techniques based on mechanical coronary obstruction. Preventive effect of agnucastoside c against isoproterenol. As it has been reported that isoproterenol can cause ischemic myocardial alterations, lipid peroxide generation and procoagulant activity, we administered it to rabbits in order to induce a noninvasive myocardial infarction associated with above mentioned. Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions. Lipid peroxidation was clearl y increased after 696 h of iso treatment as a consequence of ion superoxide formation during the preinfarction period and the nitric. Protective effect of taurine on myocardial antioxidant status in isoprenalineinduced myocardial infarction in rats. Pdf evaluation of cardioprotective role of vinpocetine.
Isoproterenollnduced myocardial infarction in rats distribution of corticosterone by jack saroff, ph. In one experiment effects of the isolated compound at 2. Blood and tissue samples liver, brain, adrenal glands, normal and necrotic areas of the heart were collected 15, 30, and 45. Agrawal, 4 santosh kumari, 5 dharamvir singh arya, 2 and shreesh ojha 2, 6. Preventive effect of agnucastoside c against isoproterenolinduced myocardial injury. The isoproterenolinduced myocardial infarction essay in rats. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles ccnp compared to conventional curcumin cc on isoproterenol iso induced myocardial infarction mi in rats. Role of nitric oxide in isoprot ernolinduced myocardial infarction 19 during mi are related with nitric oxide formation quantified by the stable products nitrite and nitrates ions. Isoproterenolinduced myocardial infarction in rats circulation. This study aims to investigate the protective effects of kefir against myocardial infarction induced by isoproterenol iso. Sham group, which underwent a virtual myocardial infarction induction, and.
Shift in antioxidant parameters, lactate dehydrogenase ldh together with morphological and histopathological changes were investigated. In the present study, we investigated the effects of histidine and vitamin c alone or in combination treatments against isoproterenol a. Isoproterenolinduced myocardial infarction in wistar rats rizwana afroz, 1,2 e. Moringa oleifera leaf extract prevents isoproterenol. Vinpocetine is a phosphodiesterase type1 inhibitor having strong vasodilating effect through camp and cgmp elevation.
Beneficial role of tamoxifen in isoproterenolinduced. Fiftysix wistarbratislava white rats were randomly divided into eight groups of seven rats each. The present study was designed to investigate the cardioprotective effects of paeonol and danshensu representative active ingredient of cortex moutan and radix salviae milthiorrhizae, respectively on isoproterenolinduced myocardial infarction in rats and its underlying mechanisms. Iso administration is followed by numerous pathophysiology and. Frontiers comparative pharmacokinetics of gallic acid.
Ginsenoside re improves isoproterenolinduced myocardial. Buddleja asiatica on isoproterenol induced myocardial necrosis in rats raja sundararajan and ramya. Effect of curcuma longa turmeric on serum creatine kinasemb and troponin i in isoproterenol induced myocardial infarction in wistar albino rats. The effect of astragaloside iv on isoproterenol induced myocardial infarction in rats article pdf available in pharmaceutical sciences 252. The model is simple in execution and the biochemical, histological and electrocardiographic changes closely mimic that seen in case of an ami. Curcumin and curcumin nanoparticles were given by gavage in three di.
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